Uricosuric action of calcium channel blocker AE0047 in rats.
نویسندگان
چکیده
منابع مشابه
Evaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEfficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia in rats.
Dihydropyridine calcium channel blockers such as nicardipine are under evaluation for treating acute cerebral ischemia because they may increase cerebral blood flow by causing vasodilation and because they may be cytoprotective in part by limiting production of arachidonic acid metabolites. We demonstrated in a previous study that nicardipine improves postischemic neuronal function, as measured...
متن کاملNatriuretic action of manidipine hydrochloride, a new calcium channel blocker, in spontaneously hypertensive rats.
Effects of manidipine, a new dihydropyridine derivative, on sodium and water excretion were examined in conscious spontaneously hypertensive rats. Manidipine (3 mg/kg) significantly increased the sodium and water excretion in the urine collected for 3 hr after the calcium antagonist was orally administered, and its natriuretic action was more prominent than those of nifedipine and nicardipine (...
متن کاملSpermatogenesis following discontinuation of calcium channel blocker amlodipine in rats.
BACKGROUND The calcium channel blockers are commonly associated with male infertility. Long-term administration of such drugs has been shown to suppress spermatogenesis. The present study was designed to determine the effects of cessation of calcium channel blocker (amlodipine) medication on spermatogenesis. METHODS The study was carried out in the Department of Physiology, in collaboration w...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1995
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)47238-7